乳业科学与技术 ›› 2025, Vol. 48 ›› Issue (4): 0-0.

• 专题论述 •    

乳蛋白肽的制备及其生物活性的研究进展

薄志航1,韦家周2,苏权2,李春梅3,刘丽波4,张国芳1,李春1,陈志成2   

  1. 1. 东北农业大学
    2. 广西农垦西江乳业有限公司
    3. 广西职业技术学院
    4. 东北农业大学乳品科学教育部重点实验室
  • 收稿日期:2025-02-28 修回日期:2025-06-04 出版日期:2025-07-01 发布日期:2025-07-28
  • 通讯作者: 薄志航
  • 基金资助:
    中央引导地方科技发展专项资金(区域创新体系建设类)中央引导地方科技发展专项资金(区域创新体系建设类)(贵科中引专项2023-3);外国专家重点支撑项目(东北专项) D20240070

Research Progress on the Preparation and Biological Activities of Milk Protein Peptides.

  • Received:2025-02-28 Revised:2025-06-04 Published:2025-07-01 Online:2025-07-28

摘要: 作为乳制品中重要的功能性蛋白资源,乳蛋白凭借其卓越的营养价值与多维度生物活性成为研究热点。近年研究在乳蛋白肽制备技术及功能解析方面取得突破性进展,通过定向酶解、可控发酵等生物加工手段可精准释放具有特定功能的活性肽段。此类活性成分在抗氧化防御、病原菌抑制、免疫稳态调节及血压调控等方面展现出显著的健康效应。本文系统综述了乳蛋白肽的制备技术,涵盖酶解法、微生物发酵法、化学合成法及计算机模拟预测技术,并对比分析了各类工艺的效能特征。研究进一步解析了乳蛋白肽的生物活性作用机制及其生物利用度特性,并评估了其在功能性食品与医药制剂领域的应用潜力。通过整合现有研究成果,本综述为优化生产工艺、拓展应用场景提供科学依据,推动乳蛋白肽的产业化发展。

关键词: 乳蛋白, 乳蛋白肽, 制备技术, 酶解法, 生物活性, 产业化应用

Abstract: As an important functional protein resource in dairy products, milk protein has become a research hotspot due to its excellent nutritional value and multi-dimensional biological activity. Recent studies have made breakthrough progress in the preparation technology and functional analysis of milk protein peptides. Through bio-processing methods such as directed enzymatic hydrolysis and controlled fermentation, bioactive peptides with specific functions can be precisely released. These active components demonstrate significant health effects in antioxidant defense, pathogen inhibition, immune homeostasis regulation, and blood pressure control. This paper systematically reviews the preparation technologies of milk protein peptides, covering enzymatic hydrolysis, microbial fermentation, chemical synthesis, and computer simulation prediction techniques, and compares and analyzes the effectiveness and characteristics of each process. The research further explains the biological activity mechanisms of milk protein peptides and their bioavailability characteristics, and evaluates their potential applications in functional foods and pharmaceutical formulations. By integrating existing research findings, this review provides a scientific basis for optimizing production processes and expanding application scenarios, promoting the industrial development of milk protein peptides.

Key words: Milk protein, Milk protein peptides, Preparation technology, Enzymatic hydrolysis, Biological activity, Industrial application.