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乳业科学与技术 ›› 2020, Vol. 43 ›› Issue (5): 26-30.DOI: 10.15922/j.cnki.jdst.2020.05.006

• 专题论述 • 上一篇    下一篇

人乳寡糖2’-岩藻糖基乳糖的生物法制备技术研究进展

徐铮, 李娜, 朱婉莹, 张雯瑞, 陈盈利, 罗正山   

  1. 南京工业大学食品与轻工学院, 材料化学工程国家重点实验室, 江苏 南京 211816
  • 出版日期:2020-09-01 发布日期:2021-11-02
  • 基金资助:
    江苏省六大人才高峰项目（NY-056）；江苏省农业科技自主创新项目（CX（20）3049）； 江苏省高等学校自然科学研究项目（20KJB530016）

Recent Advances in Bio-Production of the Human Milk Oligosaccharide 2'-Fucosyllactose (2'-FL)

XU Zheng, LI Na, ZHU Wanying, ZHANG Wenrui, CHEN Yingli, LUO Zhengshan   

  1. (State Key Laboratory of Materials-Oriented Chemical Engineering, College of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China)
  • Online:2020-09-01 Published:2021-11-02

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摘要： 人乳寡糖是母乳的重要活性成分，其中2’-岩藻糖基乳糖（2’-fucosyllactose，2’-FL）占比最高，对婴幼儿生长发育效果明显，是极具潜力的新型营养强化剂。近年来，2’-FL的生物合成方法取得长足进步，产量已经达到产业化水平，国外很多跨国公司均开始布局2’-FL的制备技术，国内高校和企业尚处于起步阶段，因此针对该项技术的探讨与研究具有重要意义。本文对2’-FL的生物制造途径进行综述，总结近年来报道的几种2’-FL合成新方法。

关键词: 人乳寡糖, 母乳, 2’-岩藻糖基乳糖, 细胞工厂, 生物工程

Abstract: Human milk oligosaccharides (HMO) are important bioactive ingredients of breast milk, the most abundant being 2’-fucosyllactose (2’-FL), which is significantly beneficial to the growth and development of infants, and is considered as a novel nutrient supplement with great potential. Recently, great progress has been made in the bio-production of 2’-FL, whose output has reached industrial levels of production. Many multi-national companies have investigated 2’-FL bio-production techniques for a long time. However, universities and companies in China have just begun research in this field, highlighting its great significance. This paper reviews the 2’-FL bio-production pathways and summarizes several recent novel 2’-FL biosynthesis methods.

Key words: human milk oligosaccharide, breast milk, 2’-fucosyllactose, cell factory, bioengineering

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