关键词: 乳制品；高效液相色谱-串联质谱；超高效液相色谱-串联质谱法；超高效液相色谱-高分辨飞行时间质谱法；基质辅助激光解吸电离-傅里叶变换离子回旋共振质谱；青霉素；代谢产物

Abstract: In this paper we review recent applications of high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS), ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), ultra high performance liquid chromatography coupled with high-resolution time-of-flight mass spectrometry (HRTOF-MS), and matrix assisted laser desorption ionization-Fourier transform ion cyclotron resonance mass spectrometry (MALDI-FTMS) to determine penicillin residues in milk and dairy products and their major enzymatic metabolites in vivo. This review describes recent progress in the development of sample extraction, purification, chromatographic separation and mass spectrometry detection methods for the determination of penicillin residues in dairy products.

Key words: dairy products; HPLC-MS/MS；UPLC-MS/MS；HRTOF-MS；MALDI-FTMS；penicillin；metabolites