Abstract: Rheumatoid arthritis is an autoimmune disease that threatens human health all over the world. Rheumatoid arthritis is closely related to intestinal microbial balance. Probiotics have been demonstrated to have the potential for treating rheumatoid arthritis as they can play an important role?in?improving gut microbiota disorder and restoring normal gut microbiota.?This?paper reviews the pathogenesis of rheumatoid arthritis and the changes in the gut microbiota of patients with rheumatoid arthritis, and summarizes research studies on the application of probiotics in alleviating rheumatoid arthritis, in order to provide a basis for further clinical trials and application of probiotics.

Key words: probiotics; rheumatoid arthritis; gut microbiota; mechanism; therapy

摘要： 类风湿关节炎是一种威胁全球人类健康的自身免疫性疾病，肠道菌群的平衡与类风湿关节炎密切相关。由于益生菌在改善肠道菌群紊乱、恢复正常肠道菌群中发挥重要作用，因此给益生菌治疗类风湿关节炎提供了可能。本文综述类风湿关节炎病因、机制及患者肠道菌群的变化，总结近年来益生菌在治疗类风湿关节炎中的研究现状，为进一步临床试验和今后的应用提供依据。

关键词: 益生菌；类风湿关节炎；肠道菌群；作用机理；治疗