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乳业科学与技术 ›› 2022, Vol. 45 ›› Issue (3): 34-38.DOI: 10.7506/rykxyj1671-5187-20211016-058

• 专题论述 • 上一篇    下一篇

益生菌对类风湿关节炎的改善作用研究进展

杨扬，刘振民，李楠   

  1. （乳业生物技术国家重点实验室，上海乳业生物工程技术研究中心，光明乳业股份有限公司乳业研究院，上海 200436）
  • 出版日期:2022-05-01 发布日期:2022-09-16
  • 基金资助:
    上海乳业生物工程技术研究中心项目（19DZ2281400）

Advances in Research and Application of Probiotics in Ameliorating Rheumatoid Arthritis

YANG Yang, LIU Zhenmin, LI Nan   

  1. (Shanghai Engineering Research Center of Dairy Biotechnology, State Key Laboratory of Dairy Biotechnology, Dairy Research Institute, Bright Dairy Co. Ltd., Shanghai 200436, China)
  • Online:2022-05-01 Published:2022-09-16

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摘要： 类风湿关节炎是一种威胁全球人类健康的自身免疫性疾病，肠道菌群的平衡与类风湿关节炎密切相关。由于益生菌在改善肠道菌群紊乱、恢复正常肠道菌群中发挥重要作用，因此给益生菌治疗类风湿关节炎提供了可能。本文综述类风湿关节炎病因、机制及患者肠道菌群的变化，总结近年来益生菌在治疗类风湿关节炎中的研究现状，为进一步临床试验和今后的应用提供依据。

关键词: 益生菌, 类风湿关节炎, 肠道菌群, 作用机理, 治疗

Abstract: Rheumatoid arthritis is an autoimmune disease that threatens human health all over the world. Rheumatoid arthritis is closely related to intestinal microbial balance. Probiotics have been demonstrated to have the potential for treating rheumatoid arthritis as they can play an important role in improving gut microbiota disorder and restoring normal gut microbiota. This paper reviews the pathogenesis of rheumatoid arthritis and the changes in the gut microbiota of patients with rheumatoid arthritis, and summarizes research studies on the application of probiotics in alleviating rheumatoid arthritis, in order to provide a basis for further clinical trials and application of probiotics.

Key words: probiotics, rheumatoid arthritis, gut microbiota, mechanism, therapy

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