Abstract: Probiotics are living microorganisms that provide health benefits to the host when consumed in certain amounts. Autoimmune diseases including systemic lupus erythematosus, multiple sclerosis, and rheumatoid arthritis are immune diseases that cause tissue and organ damage due to immune dysfunction in the body. Patients with autoimmune diseases often suffer from intestinal flora disorders. Probiotic intervention can restore intestinal microecological balance, avoiding the toxic side effects of medications, so it provides a new strategy for the prevention and treatment of autoimmune diseases. This article reviews the recent progress in research on autoimmune diseases and presents the current status and future prospects of the application of probiotic intervention strategies in autoimmune diseases.

Key words: probiotics; autoimmune diseases; gut microbiota; microbiota-based intervention; treatment prospects

摘要： 益生菌是指给予一定数量、能够对宿主健康产生有益作用的活的微生物。自身免疫性疾病是一类由于机体免疫功能紊乱而导致组织器官受损的免疫性疾病，包括系统性红斑狼疮、多发性硬化症、类风湿性关节炎等。自身免疫性疾病患者多伴随有肠道菌群紊乱的现象，通过益生菌干预恢复肠道微生态平衡，避免了药物治疗带来的毒副作用，为自身免疫性疾病的防治提供了新策略。本文回顾近年来自身免疫性疾病的研究进展，及益生菌干预策略在自身免疫性疾病中的应用现状，对其进一步应用前景予以展望。

关键词: 益生菌；自身免疫性疾病；肠道菌群；菌群干预；治疗前景