Buffalo milk is nutritious, richer in protein, fat, dry matter and minerals than cow’s milk. Buffalo milk has a high economic value, so there are currently many commercially available buffalo milk products on the Chinese market. As the climate and environment in Guangxi, China are suitable for the growth and reproduction of buffaloes. Herein is reviewed the history of the introduction of buffalo into Guangxi, the milk quality of improved hybrids of buffalo and the compositional characteristics of buffalo milk. Meanwhile, this paper compares the differences in the nutritional composition of buffalo and bovine milk, and presents an overview of the development of buffalo milk products.