This paper is intended to provide reference materials for technological innovation in the production of infant formula so as to find a breakthrough point for the development of China’s infant formula industry. In this paper, we review the course of domestic and international development of infant formula production technologies and focuse on introducing the current status of research on fortificating polyunsaturated fatty acids, modifying milk-derived proteins, stabilizing vitamins and adding oligosaccharides. This review concludes that in the futher development of infant formula, efforts should be focused on breast milk nutrition facts, infant formula classification by physiological purpose, development of ready-tofeed infant milk, fortification with immunoreactive substances, quality control of raw milk, and production management.