Quality assurance is one of the key ideas of production management in an enterprise and improving product quality is important for continuous business operation. The zero defect management requires enterprises to establish the idea of zero mistake, doing everything correctly at the beginning and pursuing perfection in every respect, that is, enterprises should change the past practice of quality inspection after the products leave the factory to prevention and control during the production process for production management. This article reviews practical applications of zero defect management in dairy enterprises. The implementation steps for zero defect management and the achievements made by its use are also outlined at last.