The objective of this study was to explore and compare the effect of different heat treatments on the stability of buffalo milk. For this purpose, milk samples were subjected to different heat treatments for the comparative determination of pH buffer capacity, total dissolved solids (TDS) content, the amount of protein precipitation and apparent viscosity. The results showed that the pH buffering capacity, TDS, protein precipitation and apparent viscosity of buffalo milk were significantly changed after heat treatments. After treatment at 121 ℃ for 15 min, the pH buffering capacity, TDS, protein precipitation and apparent viscosity reached their maximum levels, while pH buffering capacity and TDS were minimized after treatment at 95 ℃ for 5 min. Therefore, it was concluded that the stability of buffalo milk was most affected by treatments at 121℃ for 15 min and at 95 ℃ for 5 min in the experimental range investigated.