Abstract: Milk fat globule membrane (MFGM) is a three-layered biofilm present in emulsions internally encapsulated with milk fat droplets. The main components include proteins, carbohydrates, and lipids, which are mainly derived from the mammary gland cell membrane.The different protein compositions contained in MFGM have different physiological functions, including facilitating digestion, promoting neurodevelopment and reducing inflammation.This paper reviews the main protein composition of MFGM and the physicochemical properties and bioactivities of MFGM proteins, which provide some reference for the research and application of milk fat globule membrane proteins in the dairy industry and related food additives.

Key words: milk fat globules, fat globule membrane protein, structure, bioactivities

摘要： 乳脂肪球膜（milk fat globule membrane，MFGM）是一种存在于乳液中的内部包裹有乳脂肪液滴的三层生物薄膜，主要成分包括蛋白质、糖类和主要来源于乳腺细胞膜的脂质。MFGM中含有的不同蛋白组成具有不同的生理功能，包括促进消化、促进神经发育和降低炎症等。本文综述MFGM的主要蛋白组成及MFGM蛋白的理化性质和生物活性，为乳脂肪球膜蛋白在乳品行业及相关食品添加中的研究和应用提供一定的参考。

关键词: 乳脂肪球, 脂肪球膜蛋白, 结构, 生物活性