Abstract: The sample pretreatment is a critical step for the analysis of samples and has a direct impact on the analytical results. As a novel sample pretreatment technology, magnetic solid phase extraction (MSPE) is of great interest in the field of analytical testing because of its simple operation, low cost, time saving and low environmental pollution. The presence of antibiotic residues in milk is a long-standing problem, and antibiotic abuse can lead to allergies, drug resistance, secondary infection and other side effects on human health. In recent years, studies that introduce MSPE as a sample pretreatment method into antibiotic residue detection in milk have been published in large numbers. In this paper, the source and harm of antibiotic residues in milk are reviewed as well as the applications of MSPE in the detection of antibiotic residues in milk that have been reported over the past 5 years.

Key words: milk; antibiotic; magnetic solid phase extraction; applications

摘要： 前处理过程一直是样品分析的关键步骤,直接影响检测结果。作为一种新兴的样品前处理技术,磁性固相萃取(magnetic solid phase extraction,MSPE)以其操作简便、成本低廉、用时较短、环境污染小等特点成为分析检测领域的研究热点。牛乳中抗生素的残留问题由来已久,抗生素滥用可以引起机体过敏、耐药和二度感染等毒、副作用,近年来将MSPE应用于牛乳中抗生素残留检测的研究大量涌现。本文综述了牛乳中抗生素的来源与危害以及近5年来MSPE在牛乳抗生素残留检测分析中的应用情况。

关键词: 牛乳; 抗生素; 磁性固相萃取; 应用