Abstract: Breast milk is the golden standard of nutrition for newborn infants. The best way to improve infant formula is not only by simulating the composition of breast milk, but also by focusing on the structure of milk fat globule membrane (MFGM). New knowledge on MFGM has been steadily acquired. This article reviews the structure and composition of MFGM, and recent progress in understanding the effect of supplementation of MFGM in infant formula on infant growth and development, which is supported by recent clinical trials. Research in rodents has shown that adding MFGM to infant formula has benefits for intestinal digestion, physiology, and protection against pathogens and inflammation. However, there is still uncertainty about the amount and safety of MFGM added to infant formula.

Key words: milk fat globule membrane; polar lipids; infant formula; in vitro digestion; cognitive ability

摘要： 母乳被认为是新生婴儿早期所需营养的黄金标准。改善婴儿配方乳粉的最好办法除了模拟母乳的成分外， 越来越多的关注点集中在乳脂肪球的结构上，并且对乳脂肪球膜（milk fat globule membrane，MFGM）的研究越来 越深入。本文综述MFGM的结构与组成以及近年来在婴儿配方乳粉中补充MFGM对婴儿生长发育的影响，并得到 近期临床研究的支持。基于啮齿动物的研究表明，在婴儿配方乳粉中添加MFGM对肠道消化、生理健康和炎症保 护有好处，同时，大量人体实验表明，补充MFGM对婴儿的神经认知发育具有积极作用。但是，婴儿配方乳粉中 MFGM的添加量及安全性问题仍是不确定的。

关键词: 乳脂肪球膜；极性脂质；婴儿配方乳粉；体外消化；认知能力