Abstract: Hydrolysis of proteins in lactic acid bacteria fermented milk produces abundant peptides. Bioactive peptides derived from fermented milk proteins not only have rich nutritional value, but also show many biological functions such as antioxidant, blood pressure lowering, and antibacterial effects. This paper reviews various biological peptides derived from fermented milk proteins with antioxidant, antihypertensive and antimicrobial activities with respect to their mechanisms of action, sequences and structure-activity relationships. Besides, it summarizes the techniques used to identify the sequences and predict the functions of biological peptides. This review will provide a reference for the development and application in functional foods.

Key words: fermented milk, lactic acid bacteria, antioxidant peptide, antihypertensive peptide, antibacterial peptide, peptide sequence

摘要： 发酵乳经乳酸菌发酵水解后含有丰富的多肽类物质，发酵乳源生物活性肽不仅具有丰富的营养价值，还具有抗氧化、降血压、抗菌等多种生物功能。本文综述发酵乳中多种功能生物活性肽，阐明乳酸菌蛋白酶导致的生物活性肽多样性，解析抗氧化肽、抗高血压肽、抗菌肽和其他功能活性肽的作用机制、多肽序列及构效关系，最后介绍了生物活性肽的序列鉴定与功能预测技术，为其在功能性食品中的开发应用提供参考。

关键词: 发酵乳, 乳酸菌, 抗氧化肽, 降血压肽, 抗菌肽, 多肽序列