Abstract: As broad-spectrum semi-synthetic antibiotics with strong antibacterial effect and little toxic side effects, cephalosporins are widely used in livestock and poultry farming, and the food safety risk arising from this is becoming the focus of public attention. At present many governments and food safety agencies have set maximum residue limits for cephalosporin residues in milk. This paper interprets the potential health risk of cephalosporin residues in milk, and summarizes recent progress in the development of pretreatment methods and detection technologies for cephalosporin residues in milk in detail.

Key words: cephalosporins; antibiotics; milk; pretreatment methods; detection technologies

摘要： 作为一种抗菌作用强、毒副作用小的广谱半合成抗生素，头孢菌素类抗生素在畜禽养殖过程中被广泛使 用，由此产生的食品安全风险日趋成为关注焦点，当前多国政府和食品安全机构均对牛乳中头孢菌素类药物残留制 定了限量标准。本文阐述牛乳中头孢菌素类抗生素的潜在风险，详细介绍牛乳中头孢菌素类抗生素残留的预处理方 法与检测技术研究进展。

关键词: 头孢菌素类；抗生素；牛乳；预处理方法；检测技术