Abstract: Bile salt hydrolase (BSH) is considered to be especially relevant for microbes that reside in the mammalian gastrointestinal tract, which also helps to reduce the blood cholesterol level of the host. This review focuses on the occurrence of bile salt hydrolase among different microorganisms and its physiological characterization, enzyme activity, substrate specificity and genetics involved with recent updates. The current perspective reveals a huge market potential of probiotics with bile salt hydrolase.

Key words: bile salt hydrolase; bsh gene; BSH enzyme activity; structure and function

摘要： 胆盐水解酶是微生物生长、繁殖过程中产生的一种胞内酶，因其可能与降低血胆固醇、预防心血管疾病有关而受到广泛关注。本文从胆盐水解酶的特性出发，综述了胆盐水解酶的生理功能、酶学活性、微生物菌群的来源及特征，以及胆盐水解酶的氨基酸结构等方面的研究进展，以期为进一步深入研究胆盐水解酶的作用机理及相关制品的开发利用提供参考。

关键词: 胆盐水解酶；胆盐水解酶基因；胆盐水解酶酶活性；结构与功能