Abstract: The nucleus is the control center for the cell genetics and metabolism.Functional proteomics of the nucleus has become a hot topic in proteomic research.The nucleus contains many functional proteins,some of which are involved in transcriptional regulation while others are involved in nuclear-cytoplasmic transport.Proteomic detection of the state-specific activity of functional proteins is of great significance to insightful understanding of the molecular mechanisms underlying gene expression and regulation.This paper provides a review of the current research situation of functional proteomics of the cell nucleus.

Key words: nucleus;functional proteomics;

摘要： 细胞核是细胞遗传和代谢的调控中心,细胞核功能蛋白质组已成为蛋白质组学研究的热点。细胞核内含有较多的功能蛋白质,有些参与转录调控,有些参与核质转运。在蛋白质组学水平检测特定状态下细胞核中的功能蛋白活性对深入研究基因表达调控的分子机制具有重要的意义。本文就目前的细胞核功能蛋白质组学研究成果进行综述。

关键词: 动物细胞核; 功能蛋白质组学