Abstract: This study was carried out to examine if melatonin fortified UHT milk (the melatonin content is 3 mg/250 mL) has sleep-improving effects. Our results demonstrate that the fortified milk could obviously shorten the sleep onset latency of animals injected with napental, prolong sleep time and increase the number of sleeping animals injected with napental at subthreshold doses and had no direct hypnotic effect. In conclusion, melatonin fortified UHT milk has sleep-improving effects.

Key words: melatonin；milk；sleep；napental

摘要： 研究强化褪黑素超高温灭菌牛奶（褪黑素含量：3mg/250mL）对改善动物睡眠的作用。结果表明：样品能明显缩短动物注射戊巴比妥钠后的入睡时间、延长睡眠时间,可增加注射戊巴比妥钠阈下剂量后的入睡动物数,缩短注射戊巴比妥钠后的睡眠潜伏期,且无明显直接睡眠作用。因此,强化褪黑素超高温灭菌牛奶具有改善睡眠作用。

关键词: 褪黑素; 牛奶; 睡眠; 戊巴比妥钠